2023

Brockman QR, Scherer A, McGivney GR, Gutierrez WR, Rytlewski JD, Sheehan A, Warrier A, Laverty EA, Roughton G, Carnevale NC, Knepper-Adrian V, Dodd RD. Discrepancies in indel software resolution with somatic CRISPR/Cas9 tumorigenesis models. Scientific Reports. 2023 Sept 8;13:14798. doi: 10.1038/s41598-023-41109-1. PMID: 37684258

Gutierrez WR, Rytlewski JD, Scherer A, Roughton GA, Carnevale NC, Vyas KY, McGivney GR, Brockman QR, Knepper-Adrian V, Dodd RD. Loss of Nf1 and Ink4a/Arf are associated with sex-dependent growth differences in a mouse model of embryonal rhabdomyosarcoma. Current Issues in Molecular Biology. 2023 Feb 2;45(2):1218-1232 doi:10.3390/cimb45020080. PMID: 36826025

2022

Gutierrez WR, Scherer A, Rytlewski J, Laverty EA, Sheehan AP, McGivney GR, Brockman QR, Knepper-Adrian V, Roughton G, Quelle DE, Gordon DJ, Monga V, Dodd RD. Augmenting chemotherapy with low-dose decitabine through an immune-independent mechanism. JCI Insight. 2022 Oct; 7(22). doi: 10.1172/jci.insight.159419. PMID: 36227698

Brockman QR, Scherer A, McGivney GR, Gutierrez WR, Voigt AP, Isaacson AL, Laverty EA, Roughton G, Knepper-Adrian V, Darbro B, Tanas MR, Stipp CS, Dodd RD. PRC2 loss drives MPNST metastasis and matrix remodeling. JCI Insight. 2022 Oct 24; 7(20). doi: 10.1172/jci.insight.157502. PMID: 3606697

2021

Gutierrez WR, Scherer A, McGivney GR, Brockman QR, Knepper-Adrian V, Laverty EA, Roughton GA, Dodd RD. Divergent immune landscapes of primary and syngeneic Kras-driven mouse tumor models. Sci Rep. 2021 Jan 13;11(1):1098. doi: 10.1038/s41598-020-80216-1. PMID: 33441747

Kohlmeyer JL, Gordon DJ, Tanas MR, Dodd RD, Monga V, Darbro BW, Quelle DE. Combination therapies for MPNSTs targeting RABL6A-RB1 signaling. Oncotarget. 2021 Jan 5;12(1):10-14. doi: 10.18632/oncotarget.27862. PMID: 33456709

2020

Hirbe AC, Dodd RD, Pratilas CA. Special Issue: "Genomics and Models of Nerve Sheath Tumors". Genes (Basel). 2020 Sep 1;11(9):1024. doi: 10.3390/genes11091024. PMID: 32882803

Dodd RD, Scherer A, Huang W, McGivney GR, Gutierrez WR, Laverty EA, Ashcraft KA, Stephens VR, Yousefpour P, Saha S, Knepper-Adrian V, Floyd W, Chen M, Ma Y, Mastria EM, Cardona DM, Eward WC, Chilkoti A, Kirsch DG. Tumor Subtype Determines Therapeutic Response to Chimeric Polypeptide Nanoparticle-based Chemotherapy in Pten-deleted Mouse Models of Sarcoma. Clin Cancer Res. 2020 Jul 27. doi: 10.1158/1078-0432.CCR-19-2597. PMID: 32718998

Scherer A, Stephens VR, McGivney GR, Gutierrez WR, Laverty EA, Knepper-Adrian V, Dodd RD. Distinct Tumor Microenvironments Are a Defining Feature of Strain-Specific CRISPR/Cas9-Induced MPNSTs. Genes (Basel). 2020 May 23;11(5):583. doi: 10.3390/genes11050583. PMID: 32456131

Kohlmeyer JL, Gordon DJ, Tanas MR, Monga V, Dodd RD, Quelle DE. CDKs in Sarcoma: Mediators of Disease and Emerging Therapeutic Targets. Int J Mol Sci. 2020 Apr 24;21(8). doi: 10.3390/ijms21083018. Review. PMID: 32344731

Kohlmeyer JL, Kaemmer CA, Pulliam C, Maharjan CK, Samayoa AM, Major HJ, Cornick KE, Knepper-Adrian V, Khanna R, Sieren JC, Leidinger MR, Meyerholz DK, Zamba KD, Weimer JM, Dodd RD, Darbro BW, Tanas MR, Quelle DE. RABL6A Is an Essential Driver of MPNSTs that Negatively Regulates the RB1 Pathway and Sensitizes Tumor Cells to CDK4/6 Inhibitors. Clin Cancer Res. 2020 Jun 15;26(12):2997-3011. doi: 10.1158/1078-0432.CCR-19-2706. Epub 2020 Feb 21. PMID: 32086342

2018

White KA, Swier VJ, Cain JT, Kohlmeyer JL, Meyerholz DK, Tanas MR, Uthoff J, Hammond E, Li H, Rohret FA, Goeken A, Chan CH, Leidinger MR, Umesalma S, Wallace MR, Dodd RD, Panzer K, Tang AH, Darbro BW, Moutal A, Cai S, Li W, Bellampalli SS, Khanna R, Rogers CS, Sieren JC, Quelle DE, Weimer JM. A porcine model of neurofibromatosis type 1 that mimics the human disease. JCI Insight. 2018 Jun 21;3(12). doi: 10.1172/jci.insight.120402. PMID: 29925695

Peacock JD, Pridgeon MG, Tovar EA, Essenburg CJ, Bowman M, Madaj Z, Koeman J, Boguslawski EA, Grit J, Dodd RD, Khachaturov V, Cardona DM, Chen M, Kirsch DG, Maina F, Dono R, Winn ME, Graveel CR, Steensma MR. Genomic Status of MET Potentiates Sensitivity to MET and MEK Inhibition in NF1-Related Malignant Peripheral Nerve Sheath Tumors. Cancer Res. 2018 Jul 1;78(13):3672-3687. doi: 10.1158/0008-5472.CAN-17-3167. Epub 2018 May 2. PMID: 29720369

2017

Huang J, Chen M, Whitley MJ, Kuo HC, Xu ES, Walens A, Mowery YM, Van Mater D, Eward WC, Cardona DM, Luo L, Ma Y, Lopez OM, Nelson CE, Robinson-Hamm JN, Reddy A, Dave SS, Gersbach CA, Dodd RD, Kirsch DG. Generation and comparison of CRISPR-Cas9 and Cre-mediated genetically engineered mouse models of sarcoma. Nat Commun. 2017 Jul 10;8:15999. doi: 10.1038/ncomms15999. PMID: 28691711

Dodd RD, Lee CL, Overton T, Huang W, Eward WC, Luo L, Ma Y, Ingram DR, Torres KE, Cardona DM, Lazar A, Kirsch DG. NF1+/- hematopoietic cells accelerate malignant peripheral nerve sheath tumor development without altering chemotherapy response.  Cancer Res. 2017 Jun 23. pii: canres.2643.2016. doi: 10.1158/0008-5472.CAN-16-2643. PMID: 28646022

2016

ldham M, Yoon P, Fathi Z, Beyer WF, Adamson J, Liu L, Alcorta D, Xia W, Osada T, Liu C, Yang XY, Dodd RD, Herndon JE 2nd, Meng B, Kirsch DG, Lyerly HK, Dewhirst MW, Fecci P, Walder H, Spector NL. X-Ray Psoralen Activated Cancer Therapy (X-PACT). PloS one. 2016; 11(9):e0162078. PMID: 27583569  

Dodd RD, Sachdeva M, Mito JK, Eward WC, Brigman BE, Ma Y, Dodd L, Kim Y, Lev D, Kirsch DG. Myogenic transcription factors regulate pro-metastatic miR-182. Oncogene. 2016; 35(14):1868-75. NIHMSID: NIHMS692633. PMID: 26234681

Dodd RD. Emerging targets in sarcoma: Rising to the challenge of RAS signaling in undifferentiated pleomorphic sarcoma. Cancer. 2016; 122(1):17-9. PMID: 26479175

2002-2015

Sachdeva M, Dodd RD, Huang Z, Grenier C, Ma Y, Lev DC, Cardona DM, Murphy SK, Kirsch DG. Epigenetic silencing of Kruppel like factor-3 increases expression of pro-metastatic miR-182. Cancer letters. 2015; 369(1):202-11. NIHMSID: NIHMS718827. PMID: 26314219

Dodd RD, Añó L, Blum JM, Li Z, Van Mater D, Kirsch DG. Methods to generate genetically engineered mouse models of soft tissue sarcoma. Methods in molecular biology (Clifton, N.J.). 2015; 1267:283-95. PMID: 25636474

Sachdeva M, Mito JK, Lee CL, Zhang M, Li Z, Dodd RD, Cason D, Luo L, Ma Y, Van Mater D, Gladdy R, Lev DC, Cardona DM, Kirsch DG. MicroRNA-182 drives metastasis of primary sarcomas by targeting multiple genes. The Journal of clinical investigation. 2014; 124(10):4305-19. PMID: 25180607

Blum JM, Añó L, Li Z, Van Mater D, Bennett BD, Sachdeva M, Lagutina I, Zhang M, Mito JK, Dodd LG, Cardona DM, Dodd RD, Williams N, Ma Y, Lepper C, Linardic CM, Mukherjee S, Grosveld GC, Fan CM, Kirsch DG. Distinct and overlapping sarcoma subtypes initiated from muscle stem and progenitor cells. Cell reports. 2013; 5(4):933-40. NIHMSID: NIHMS532505. PMID: 24239359

Dodd RD, Mito JK, Eward WC, Chitalia R, Sachdeva M, Ma Y, Barretina J, Dodd L, Kirsch DG. NF1 deletion generates multiple subtypes of soft-tissue sarcoma that respond to MEK inhibition. Molecular cancer therapeutics. 2013; 12(9):1906-17. NIHMSID: NIHMS507213. PMID: 23858101

Epple LM, Dodd RD, Merz AL, Dechkovskaia AM, Herring M, Winston BA, Lencioni AM, Russell RL, Madsen H, Nega M, Dusto NL, White J, Bigner DD, Nicchitta CV, Serkova NJ, Graner MW. Induction of the unfolded protein response drives enhanced metabolism and chemoresistance in glioma cells. PloS one. 2013; 8(8):e73267. PMID: 24039668

Mito JK, Ferrer JM, Brigman BE, Lee CL, Dodd RD, Eward WC, Marshall LF, Cuneo KC, Carter JE, Ramasunder S, Kim Y, Lee WD, Griffith LG, Bawendi MG, Kirsch DG. Intraoperative detection and removal of microscopic residual sarcoma using wide-field imaging. Cancer. 2012; 118(21):5320-30.​PMID: 22437667

Kim S, Dodd RD, Mito JK, Ma Y, Kim Y, Riedel RF, Kirsch DG. Efficacy of phosphatidylinositol-3 kinase inhibitors in a primary mouse model of undifferentiated pleomorphic sarcoma. Sarcoma. 2012; 2012:680708. ​PMID: 22619567

Dodd RD, Mito JK, Kirsch DG. Animal models of soft-tissue sarcoma. Disease models & mechanisms. 2010; 3(9-10):557-66. PMID: 20713645

Mito JK, Riedel RF, Dodd L, Lahat G, Lazar AJ, Dodd RD, Stangenberg L, Eward WC, Hornicek FJ, Yoon SS, Brigman BE, Jacks T, Lev D, Mukherjee S, Kirsch DG. Cross species genomic analysis identifies a mouse model as undifferentiated pleomorphic sarcoma/malignant fibrous histiocytoma. PloS one. 2009; 4(11):e8075. PMID: 19956606

Yoon SS, Stangenberg L, Lee YJ, Rothrock C, Dreyfuss JM, Baek KH, Waterman PR, Nielsen GP, Weissleder R, Mahmood U, Park PJ, Jacks T, Dodd RD, Fisher CJ, Ryeom S, Kirsch DG. Efficacy of sunitinib and radiotherapy in genetically engineered mouse model of soft-tissue sarcoma. International journal of radiation oncology, biology, physics. 2009; 74(4):1207-16. NIHMSID: NIHMS130311. PMID: 19545786

Stephens SB, Dodd RD, Lerner RS, Pyhtila BM, Nicchitta CV. Analysis of mRNA partitioning between the cytosol and endoplasmic reticulum compartments of mammalian cells. Methods in molecular biology (Clifton, N.J.). 2008; 419:197-214.PMID: 18369985

Nicchitta CV, Lerner RS, Stephens SB, Dodd RD, Pyhtila B. Pathways for compartmentalizing protein synthesis in eukaryotic cells: the template-partitioning model. Biochemistry and cell biology = Biochimie et biologie cellulaire. 2005; 83(6):687-95.PMID: 16333319

Stephens SB, Dodd RD, Brewer JW, Lager PJ, Keene JD, Nicchitta CV. Stable ribosome binding to the endoplasmic reticulum enables compartment-specific regulation of mRNA translation. Molecular biology of the cell. 2005; 16(12):5819-31. PMID: 16221886

Tyulina OV, Prokopieva VD, Dodd RD, Hawkins JR, Clay SW, Wilson DO, Boldyrev AA, Johnson P. In vitro effects of ethanol, acetaldehyde and fatty acid ethyl esters on human erythrocytes. Alcohol and alcoholism (Oxford, Oxfordshire). 2002; 37(2):179-86. PMID: 11912075